fentanyl transdermal and chlorzoxazone the two enhance sedation. Steer clear of or Use Alternate Drug. Limit use to clients for whom alternative cure choices are insufficient
brivaracetam and fentanyl transdermal each maximize sedation. Prevent or Use Alternate Drug. Limit use to clients for whom different remedy options are inadequate
phenobarbital will lessen the extent or impact of fentanyl transdermal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Observe Carefully. Coadministration of fentanyl with CYP3A4 inducers could lead on into a lessen in fentanyl plasma concentrations, lack of efficacy or, perhaps, improvement of the withdrawal syndrome in a affected individual who has made Bodily dependence to fentanyl.
duvelisib will enhance the stage or result of fentanyl transdermal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Closely. Coadministration with duvelisib improves AUC of a delicate CYP3A4 substrate which may increase the threat of toxicities of these drugs.
istradefylline will enhance the stage or effect of fentanyl transdermal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.
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fentanyl transdermal, clemastine. Either boosts toxicity of the opposite by pharmacodynamic synergism. Modify Therapy/Monitor Intently. Coadministration of fentanyl with anticholinergics could improve hazard for urinary retention and/or critical constipation, which may produce paralytic ileus.
buprenorphine decreases outcomes of fentanyl transdermal by pharmacodynamic antagonism. Keep away from or Use Alternate Drug. Coadministration of blended agonist/antagonist and partial agonist opioid analgesics may perhaps lower fentanyl's analgesic result And perhaps precipitate withdrawal signs or symptoms.
Preserve fentanyl from get to of children and pets. Never toss medicines into a garbage bin or flush them down the rest room, as This is often dangerous to others and destructive to the environment.
Just after many increments of intravenous midazolam and nalbuphine had been gradually titrated, the affected person turned increasingly far more restless and disoriented. My respond to to his telephone get in touch with trying to find my information included the subsequent tips:
ketoconazole will enhance the amount or effect of fentanyl transdermal by impacting hepatic/intestinal enzyme CYP3A4 metabolism.
Fentanyl influences Every person in different ways. Should you have any of those Unwanted effects although using fentanyl, or should you observe something that is certainly building you're feeling unwell, speak with your pharmacist or health practitioner.
fentanyl transdermal, dimenhydrinate. Both boosts toxicity of one other by pharmacodynamic synergism. Modify Therapy/Observe Carefully. Coadministration of fentanyl with anticholinergics might enhance risk for urinary retention and/or severe constipation, which may lead to paralytic ileus.
fentanyl transdermal and nortriptyline equally raise sedation. Avoid or Use Alternate website Drug. Restrict use to people for whom alternative therapy alternatives are inadequate